Substitution therapy is a term used to describe a harm reduction treatment for opioid use disorders where safer versions of the drug substitute for the unsafe, illegal forms. The most common types of substitution therapy are methadone and buprenorphine. However, the term can also refer to a treatment modality for skin picking disorder, where the client learns to replace skin picking behaviors with a different activity, such as physical exercise or creative activities as painting or writing. This technique may benefit people whose underlying psychological energy accumulates and picking relieves the tension. Redirecting this energy towards positive activities can not only free the person from harmful behaviors, but create positive results for quality of life.